来自脂肪细胞的N-乙酸调节了饭后的体温
Jessica B Felix1,2,3, Pradip K Saha1,2, Evelyn de Groot1,2,4
1Division of Diabetes, Endocrinology, and Metabolism, Baylor College of Medicine, Houston, TX.
Research square
|January 23, 2024
概括
白色脂肪组织 (WAT) 产生N-乙酸 (NAA),调节饭后的体温. 这一发现揭示了WAT衍生的NAA作为生理恒常的关键内分泌调节器.
科学领域:
- 代谢学 代谢学 代谢学
- 内分泌学 在内分泌学.
- 生理学 生理学 生理学
背景情况:
- N-乙酸 (NAA) 在大脑中丰富,对髓化至关重要.
- 在其他组织中NAA的作用和活动在很大程度上是未知的.
研究的目的:
- 研究阿斯巴尔托酶 (ASPA) 和NAA在白色脂肪组织 (WAT) 中的生理作用.
- 确定WAT衍生的NAA在全身代谢调节和体温控制中的作用.
主要方法:
- 使用AspA淘汰赛小鼠模型 (全身和组织特定).
- 采用蛋白质组学,质谱学和稳定同位素追踪.
- 在人体中分析了血清NAA与金胺中间体的相关性.
主要成果:
- 在AspA淘汰赛小鼠的WAT中NAA的积累刺激了酸通路和pyrimidine生产.
- 脂肪细胞被证明可以提供血NAA,抑制食后体温升高.
- 血清NAA与 orotidine 有积极的相关性,预测人类的下体质指数.
结论:
- 在WAT中的ASPA表达调节系统NAA水平和食后体温.
- 来自WAT的NAA作为内分泌调节剂,影响生理恒温.
- NAA在温度调节和代谢健康方面发挥了以前未知的作用.
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