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Updated: Jul 5, 2025

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里姆4是一个热传感器和驱动器,用于介质变化特定的压力颗粒

Rudian Zhang, Shunjin Li, Wenzhi Feng

bioRxiv : the preprint server for biology

|January 23, 2024

概括

热能触发Rim4蛋白在半变化过程中自我组装,形成压力颗粒,阻止进展并保护细胞组件. 这种机制允许在缓解热应力后快速恢复.

科学领域:

细胞生物学细胞生物学
分子生物学分子生物学
遗传学遗传学是一个

背景情况:

里姆4是一种化特异性RNA结合蛋白 (RBP),通过分离抑制mRNA转化.
已知Rim4的C端低复杂性域 (LCD) 形成了粉样类聚合物.

结论:

在温度波动下,Rim4介导的热应力反应对于防止介质错误至关重要.
里姆4自我组装的可逆性质及其在SG中的作用有助于细胞弹性和中介性停止后的恢复.

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