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人类冠状病毒HKU1对TMPRSS2宿主受体的识别

Matthew McCallum1, Young-Jun Park1,2, Cameron Stewart1

  • 1Department of Biochemistry, University of Washington, Seattle, Washington, USA.

bioRxiv : the preprint server for biology
|January 23, 2024
PubMed
概括

人类冠状病毒HKU1使用TMPRSS2蛋白酶进入细胞. 研究人员使用冷EM绘制了这种相互作用,揭示了HKU1如何与TMPRSS2接触并逃避免疫反应.

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Coronavirus01:29

Coronavirus

Coronaviruses, including the severe acute respiratory syndrome coronavirus (SARS-CoV), are enveloped viruses characterized by their single-stranded, positive-sense RNA genome and helical nucleocapsid structure. The hallmark of these viruses is their club-shaped spike (S) glycoproteins that protrude from the viral envelope, facilitating attachment to host cells. Typically, coronaviruses infect the upper respiratory tract, often causing mild or asymptomatic disease. However, certain strains like...