人类大脑中的神经元微观结构变化与神经认知衰老有关
Kavita Singh1, Stephanie Barsoum1, Kurt G Schilling2
1Multiscale Imaging and Integrative Biophysics Unit, National Institute on Aging, NIH, Baltimore, MD, USA.
bioRxiv : the preprint server for biology
|January 23, 2024
概括
扩散MRI揭示了与衰老和认知衰退相关的早期微观结构性大脑变化,先于可见缩. 这些微妙的变化,而不是宏观的变化,与老年人的神经行为表现相关.
科学领域:
- 神经成像是一种神经成像.
- 衰老研究研究 衰老研究
- 神经科学是一个神经科学.
背景情况:
- 灰质 (GM) 变化与衰老和痴呆症有关.
- 像皮层厚度这样的宏观MRI指标可能无法检测早期衰老相关的变化.
- 扩散MRI为敏感的微结构变化检测提供了潜在的潜力.
研究的目的:
- 探索扩散MRI作为与年龄相关的灰质微观结构变化的标记.
- 评估这些微观结构变化与认知/行为缺陷之间的关联.
- 调查微观结构变化是否先于宏观缩和认知衰退.
主要方法:
- 使用了人类连接体项目-衰老队列 (N=707,年龄36-90岁).
- 将平均明显扩散传播器模型应用于扩散MRI数据.
- 测量了微观结构参数,并将它们与认知和行为测试成绩相关联.
主要成果:
- 宏观和微观结构的转基因测量都与年龄有很强的相关性.
- 微观结构的变化反映了细胞的变化,减少了密度,并增加了细胞外体积.
- 在宏观的GM体积和神经行为性能之间没有发现任何关联.
- 皮层和皮层下微观结构的改变与神经行为表现有关.
结论:
- 微观结构的变化,包括异质性和神经元分散的减少,可能会在宏观灰质变化之前发生.
- 这些微观结构变化被认为是神经认知表现的早期标志物.
- 扩散MRI标记可以帮助识别表型衰老和功能衰退的机制.
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