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Updated: Jul 5, 2025

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在DNA复制过程中,FANCJ促进了PARP1活动,这在BRCA1缺陷细胞中至关重要

Ke Cong, Nathan MacGilvary, Silviana Lee

    bioRxiv : the preprint server for biology
    |January 23, 2024
    PubMed
    概括

    聚 (ADP-ribose) 聚合酶抑制剂 (PARPi) 的有效性取决于FANCJ螺旋酶,它可以防止G-四重复合体对PARP1进行隔离. 通过损害与复制相关的PARP1活性,FANCJ损失会增加PARPi的抗性.

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