在复杂的环境中,N-cadherin动态调节儿科质瘤细胞迁移
Dayoung Kim1, James M Olson2,3, Jonathan A Cooper1
1Basic Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, 98109, USA.
bioRxiv : the preprint server for biology
|January 23, 2024
概括
儿科高度质瘤细胞通过调节N-cadherin相互作用来适应迁移. 这种蛋白质的蛋白质.
科学领域:
- 神经瘤学神经瘤学
- 细胞生物学 细胞生物学
- 生物化学 生化学
背景情况:
- 儿科高度质瘤是侵略性的,侵入性的,并且在很大程度上是无法治愈的脑瘤.
- 了解复杂微环境中的质瘤细胞迁移机制至关重要.
- N-cadherin表达与儿科质瘤的生存率较差相关.
研究的目的:
- 调查N-cadherin在儿童质瘤细胞跨不同微环境迁移中的作用.
- 阐明N-cadherin动态和细胞相互作用如何影响入侵和生存.
主要方法:
- 在儿科质瘤中分析N-cadherin表达和局部化.
- 在神经元,星细胞和细胞外基质上的体外迁移测定.
- 评估YAP1/TAZ信号传递和细胞增殖在领导者和追随者细胞.
主要成果:
- N-cadherin相互作用差异调节迁移:刺激神经元/星细胞,抑制细胞外基质.
- N-cadherin的局部化有所不同:在领导细胞中具有丝状,在追随细胞中具有上皮状.
- 领导细胞表现出更高的表面/循环N-cadherin,增加了YAP1/TAZ信号和增殖.
结论:
- 儿科质瘤细胞动态调节N-cadherin和细胞-细胞接触,以适应迁移到不同的微环境.
- 在迁移过程中,YAP1/TAZ信号传输在调节N-cadherin动态方面发挥着关键作用.
- 准N-cadherin相互作用可能为儿科质瘤提供新的治疗策略.
关键词:
这是一种N-cadherin.一个YAP1一个YAP1细胞对细胞的粘附.集体迁移,集体迁移.细胞内分泌症 (endocytosis) 是一种细胞内分泌症.领导细胞的领导细胞.儿科大脑瘤 儿科大脑瘤儿科高度结质瘤 儿童高度结质瘤更多相关视频
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