相关实验视频

Updated: Jul 5, 2025

Facial Transplants in Xenopus laevis Embryos

Facial Transplants in Xenopus laevis Embryos

Published on: March 26, 2014

在Xenopus laevis中,Dyrk1a是面部发育所需的

H Katherine Johnson, Stacy E Wahl, Fatmata Sesay

bioRxiv : the preprint server for biology

|January 23, 2024

概括

双重特异性铁酸酸化调节激酶1A (DYRK1A) 基因中的功能突变损失导致面形. 在Xenopus胚胎中DYRK1A缺乏导致由于细胞生长和死亡的改变而导致更小的面部和下巴.

科学领域:

发展生物学发展生物学
遗传学是一个遗传学.
头骨面部的发展

背景情况:

DYRK1A基因中的功能丧失突变与人类面形有关.
了解这些缺陷背后的精确机制对于开发治疗策略至关重要.

结论:

在面发育过程中,DYRK1A在调节细胞增殖和细胞亡方面发挥着至关重要的作用.
DYRK1A功能的缺陷会扰乱分支中神经峰衍生的结构的发展.
这项研究为与DYRK1A突变相关的面出生缺陷的病因提供了新的见解.

更多相关视频

Dissection of Xenopus laevis Neural Crest for in vitro Explant Culture or in vivo Transplantation

Dissection of Xenopus laevis Neural Crest for in vitro Explant Culture or in vivo Transplantation

Published on: March 4, 2014

Quantification of Orofacial Phenotypes in Xenopus

Quantification of Orofacial Phenotypes in Xenopus

Published on: November 6, 2014

相关概念视频

Determination

Determination

During embryogenesis, cells become progressively committed to different fates through a two-step process: specification followed by determination. Specification is demonstrated by removing a segment of an early embryo, “neutrally” culturing the tissue in vitro—for example, in a petri dish with simple medium—and then observing the derivatives. If the cultured region gives rise to cell types that it would normally generate in the embryo, this means that it is specified. In...