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Updated: Jul 5, 2025

Engineering Cell-permeable Protein

Engineering Cell-permeable Protein

Published on: December 28, 2009

秘密粒子信息传输 (SPIT) - 一个用于生物基因工程的蜂平台

Carsten T Charlesworth¹, Shota Homma^1,2, Fabian Suchy^1,2

¹Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Lorry I. Lokey Stem Cell Research Building, 265 Campus Drive, Stanford, CA, USA.

bioRxiv : the preprint server for biology

|January 23, 2024

概括

科学家们开发了秘密粒子信息传输 (SPIT),这是一种用于体内基因工程的新型细胞方法. 这种方法使用人类细胞提供基因编辑工具,如CRISPR-Cas9,成功修改小鼠的器官和干细胞.

科学领域:

生物技术是生物技术.
分子生物学分子生物学
基因治疗基因治疗

背景情况:

有精确的基因组操纵工具,但临床应用受到交付挑战的阻碍.
在体内有效和有针对性地提供基因工程工具仍然是治疗开发的重大障碍.

结论:

SPIT利用人类细胞的自然能力进行大规模的遗传编程和长期植入.
预计SPIT将成为推动体内基因工程及其临床应用的变革性方法.
突出了利用细胞载体在各种组织中进行复杂的遗传修饰的潜力.

关键词:

基因编辑CRISPR基因编辑细胞工程细胞工程人类细胞载体人类细胞载体在活体基因治疗中,基因疗法纳米医学发展纳米医学的发展再生医学是一种再生医学.干细胞向向的目标合成生物学合成生物学系统性交付系统性交付这就是VLP的VLP.

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