在大麻引起的精神病中异常突出:一项比较研究
Valerio Ricci1, Ilenia Di Muzio2, Franca Ceci2
1Department of Neuroscience, San Luigi Gonzaga University Hospital, Orbassano, Italy.
Frontiers in psychiatry
|January 23, 2024
概括
与天然大麻使用者和非使用者相比,合成大麻素 (SPICE) 用户经历了更严重的精神病症状和更差的功能. 在SPICE使用者中,异常突出性 (AS) 较高,表明它在物质诱导的精神病中发挥了作用.
科学领域:
- 精神病学是一个精神病学.
- 神经科学是一个神经科学.
- 大麻素研究 研究 大麻素研究
背景情况:
- 大麻的使用,无论是天然 (NC) 还是合成 (SC),都与精神疾病的风险和严重性增加有关.
- 异常突出 (AS) 是一种结构,涉及过度赋予中性刺激的意义,可能导致精神病的发病和维持.
- AS可能在精神病障碍的发展和延续中发挥关键作用.
研究的目的:
- 为了比较非使用者,NC用户和SC用户中精神病的过程.
- 在这些群体中调查精神病症状,分离症状,AS,全球功能和自杀念头的差异.
- 阐明AS在物质诱导与非物质相关精神病中的作用.
主要方法:
- 一组62名第一发精神病 (FEP) 患者被分为三组:非使用者 (N=20),NC/THC使用者 (N=21) 和SC/SPICE使用者 (N=20).
- 患者在基线,3个月和6个月被评估,使用验证的精神病 (PANSS),功能 (GAF),解离 (DES-II),自杀念头 (SSI) 和AS (ASI) 的尺度.
主要成果:
- 香料使用者表现出更严重和持久的积极症状;非使用者主要表现出负面症状.
- 与SPICE用户相比,非使用者表现出更好的整体功能恢复.
- 所有组随着时间的推移显示AS得分下降,但SPICE用户保持了更高的全球AS水平,改善较少.
结论:
- 异常突出 (AS) 在物质诱导精神病的过程中显著涉及,特别是在合成大麻素使用时.
- 了解AS的作用可以帮助区分和诊断与物质相关的与非物质相关的精神病.
- 这项研究可能会根据物质使用和AS水平为精神病量身定制的精神药物治疗提供信息.
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