在最近减肥后诊断出癌症
Qiao-Li Wang1,2, Ana Babic1, Michael H Rosenthal3,4
1Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Harvard University, Boston, Massachusetts.
JAMA
|January 23, 2024
概括
医疗专业人员无法解释的体重减轻与在接下来的一年内患癌症的风险增加有关. 这种关联在上胃肠道癌症中尤为明显.
科学领域:
- 癌症学
- 流行病学
- 预防医学
背景情况:
- 无法解释的体重减轻是一种常见的临床观察.
- 最近减肥与随后的癌症风险之间的关联尚不清楚.
研究的目的:
- 在减肥的卫生专业人员中调查癌症诊断率.
- 为了比较最近减肥和没有减肥的个体的癌症发病率.
主要方法:
- 护士健康研究和卫生专业人员后续研究的前性队列分析.
- 每两年评估体重变化;根据饮食和体力活动分类的意向性.
- 在体重变化后的12个月内追踪的癌症诊断.
主要成果:
- 体重减轻超过10%的参与者,癌症发病率明显高 (1362/ 100,000 人/ 年),而没有 (869/ 100,000 人/ 年).
- 与对照组 (1220/100,000人/年) 相比,低意向减肥病例的癌症风险明显增加.
- 在减肥组 (173/100,000人/年) 与对照组 (36/100,000人/年) 中,上胃肠道癌症的发生率明显高.
结论:
- 医疗专业人员最近的减肥与癌症风险显著增加有关.
- 在最近体重减轻的人群中,胃肠上部癌症的比例不成比例.
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