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一个患有甲基荷胺分泌神经母细胞瘤的患者的严重不稳定性高血压:一个病例报告
Jeanne Frisby-Zedan1,2, Michael Migotsky3,4, David O Walterhouse3,4
1Ann and Robert H. Lurie Children's Hospital of Chicago, 225 E Chicago Ave, Chicago, IL, 60611, USA. jfrisbyzedan@luriechildrens.org.
Pediatric nephrology (Berlin, Germany)
|January 23, 2024
概括
这项案例研究突出了在接受神经母细胞瘤治疗的儿童中罕见的严重的耐药高血压病例. 它强调在化疗期间仔细监测血压,因为可能会释放catecholamine.
科学领域:
- 儿科瘤学 儿科瘤学
- 心血管生理学心血管生理学
- 神经科学是一个神经科学.
背景情况:
- 神经母细胞瘤是一种儿科交感神经系统瘤,影响25%的高血压患者.
- 一名4岁的女性出现高血压紧急情况和末端器官损伤,包括PRES和脑梗塞.
- 这名患者患有巨大的腹部分泌甲醇胺的神经母细胞瘤,压缩血管和下腔静脉.
研究的目的:
- 在神经母细胞瘤化疗期间描述一个不寻常的不稳定,多药耐药高血压病例.
- 为这个复杂的临床场景提供潜在的管理策略.
主要方法:
- 一个4岁的女性患有神经母细胞瘤的病例报告.
- 化学疗法给药,然后进行手术切除.
- 监测和管理高血压紧急情况及其并发症.
主要成果:
- 患者在化疗期间经历了不稳定,多药耐药的高血压.
- 高血压紧急情况导致后部可逆脑病综合征,急性脑梗塞和心脏缩.
- 在化疗后进行了手术切除.
结论:
- 在神经母细胞瘤化疗期间,密切监测和迅速管理高血压至关重要.
- 瘤溶解可以加速甲醇胺的释放,加剧高血压.
- 这一案例强调了小儿瘤病患神经母细胞瘤和高血压的警的重要性.
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