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Updated: Jul 5, 2025

Novel Methods for Intranasal Administration Under Inhalation Anesthesia to Evaluate Nose-to-Brain Drug Delivery
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鼻内纳洛重复剂量策略和芬太尼尔过量服用:基于模拟的随机临床试验

David G Strauss1, Zhihua Li1, Anik Chaturbedi1

  • 1Division of Applied Regulatory Science, Office of Clinical Pharmacology, Office of Translational Sciences, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland.

JAMA network open
|January 23, 2024
PubMed
概括

对于芬太尼过量服用,标准的鼻内纳洛剂量可能不足. 与单次剂量相比,四次或两次重复注射鼻内纳洛显著增加了血度,这表明在逆转芬太尼的影响方面效率有所提高.

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