口腔癌发生率和生存趋势:一个基于人口的研究
Nitin M Gangane1, Pravinkumar V Ghongade, Bharat U Patil
1Department of Pathology, Mahatma Gandhi Institute of Medical Sciences, Sevagram, Wardha, Maharashtra, India.
Journal of cancer research and therapeutics
|January 23, 2024
概括
口腔癌 (OCC) 的发病率在年轻人中正在上升,死亡率高,生存率低. 诸如50岁以上的年龄,一次性治疗和特定的癌症部位等因素会使生存率恶化,这凸显了通过查早期检测的必要性.
科学领域:
- 在瘤学瘤学.
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 口腔癌 (OCC) 在全球范围内对健康造成重大负担.
- 了解OCC的发病率,死亡率和生存率对于公共卫生倡议至关重要.
- 确定预后因素可以帮助风险分层和治疗规划.
研究的目的:
- 确定口腔癌 (OCC) 的发病率,死亡率和生存率.
- 研究临床病理学,人口统计学和治疗因素对OCC结果的影响.
- 分析OCC的趋势,特别是在年轻人群中.
主要方法:
- 从印度基于人口的癌症注册表 (2010-2016) 追溯分析了1051例OCC病例.
- 使用年龄标准化方法计算发病率和死亡率.
- 对于生存结果的卡普兰-梅尔分析和预后因素估计的Cox比例危险回归.
主要成果:
- 对OCC的年龄标准化发病率和死亡率分别为每10万人口中的10.1和8.4.
- 对OCC的五年总生存率为32.3%,受到治疗和解剖部位的显著影响.
- 在50岁以上的个体 (HR=2.065) 和组合疗法 (HR=2.630) 中观察到死亡风险增加. 与唇癌相比,桃体癌显示死亡风险更高.
结论:
- 口腔癌 (OCC) 越来越多地影响年轻人群,其特点是死亡率高,存活率降低.
- 与低生存率相关的预后因素包括年龄>50岁,单种治疗方式和桃体或气泡恶性瘤.
- 医疗保健专业人员加强查对于早期检测,提高认识和降低OCC死亡率至关重要.
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