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Updated: Jul 5, 2025

Cellular Membrane Affinity Chromatography Columns to Identify Specialized Plant Metabolites Interacting with Immobilized Tropomyosin Kinase Receptor B
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使用生成建模来赋予最初惰性化合物具有良好的生物可用性和低毒性的功效

Robert I Horne1, Jared Wilson-Godber1, Alicia González Díaz1

  • 1Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, United Kingdom.

Journal of chemical information and modeling
|January 23, 2024
PubMed
概括

从具有良好的药物代谢和药理动力学 (DMPK) 特性的非活性化合物开始药物发现,可以克服早期成功的挑战. 机器学习成功地建立了阻碍α-synuclein聚合到这些化合物的抑制活性.

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