相关实验视频

Updated: Jul 5, 2025

Optical Detection of E. coli Bacteria by Mesoporous Silicon Biosensors

Optical Detection of E. coli Bacteria by Mesoporous Silicon Biosensors

Published on: November 20, 2013

在离子共价有机框架中的诱导极化效应对称局部内置电场用于选择性成像和杀死细菌

Jianfang Li¹, Huiqin Jin¹, Tao Qin²

¹School of Chemistry and Chemical Engineering, Shanxi University, Taiyuan 030006, People's Republic of China.

|January 23, 2024

概括

阴离子共价有机框架 (COF) 提供了一种新的抗生素替代品. 工程化COF利用局部电场来增强对Gram阳性细菌的光催化抗菌活性.

科学领域:

材料科学材料科学材料科学
纳米技术纳米技术
摄影化学的使用.

背景情况:

光催化材料显示出作为抗生素替代品的希望.
光生成载体的快速重组限制了抗菌效率.

研究的目的:

设计一种具有增强光催化抗菌性能的阴离子共价有机框架 (COF).
研究局部电场在抑制载体重组和增加活性氧物种 (ROS) 产量的作用.
开发一种针对格拉姆阳性细菌的向抗菌剂.

主要方法:

合成了一个带有Zn-和瓜尼尼单位的阴离子COF.
使用密度函数理论 (DFT) 计算来分析电子结构和电场分布.
通过DSPE-PEG2000对COF进行了功能化,以实现有针对性的交付.
在光照照射下对黄金葡萄球菌 (Staphylococcus aureus) 和菌 (Enterococcus faecalis) 进行抗菌疗效评估.

主要成果:

由于诱导极化,COF表现出一个对称的局部电场,抑制载体重组.
DFT计算证实了对称的电友/核友区域,增强了ROS生成.
DSPE-PEG2000的功能使得通过脂铁酸相互作用能够选择性向格拉姆阳性细菌.
在20分钟的光照照射下,在2.00ppm下实现了S. aureus (99.75%) 和E. faecalis (99.77%) 的快速杀死.

结论:

具有内置电场的工程化COF可以显著增强光催化抗菌活性.
在COF中充电行为工程为开发新的光响应抗菌剂提供了一个有希望的策略.
这种向的纳米粒子系统证明了高效率对抗格拉姆阳性细菌.

关键词:

电子转移是电子的转移.离子共价有机框架的有机框架消毒消毒消毒消毒消毒消毒对称的本地化内置电场.准的是格拉姆阳性细菌.

更多相关视频

LED-Based In Vitro Screening for Assessing Photoactivable Molecules in Bacterial Photodynamic Inactivation

LED-Based In Vitro Screening for Assessing Photoactivable Molecules in Bacterial Photodynamic Inactivation

Published on: January 24, 2025

High Spatial Resolution Chemical Imaging of Implant-Associated Infections with X-ray Excited Luminescence Chemical Imaging Through Tissue

High Spatial Resolution Chemical Imaging of Implant-Associated Infections with X-ray Excited Luminescence Chemical Imaging Through Tissue

Published on: September 30, 2022

相关概念视频

Induced Electric Dipoles

Induced Electric Dipoles

A permanent electric dipole orients itself along an external electric field. This rotation can be quantified by defining the potential energy because the external torque does work in rotating it. Then, the potential energy is minimum at the parallel configuration and maximum at the antiparallel configuration. While the former is a stable equilibrium, the latter is an unstable equilibrium.
Since the absolute value of potential energy holds no physical meaning, its zero value can be chosen as per...

π Electron Effects on Chemical Shift: Overview

π Electron Effects on Chemical Shift: Overview

An applied magnetic field causes loosely bound π-electrons in organic molecules to circulate, producing a local or induced diamagnetic field over a large spatial volume. As the molecules tumble in solution, the field generated by π-electrons in spherical substituents results in a zero net field. However, the net field generated by π-electrons in non-spherical substituents is not zero. The effect of this induced field depends on the orientation of the molecule with respect to B0,...

Potential Due to a Polarized Object

Potential Due to a Polarized Object

A neutral atom consists of a positively charged nucleus surrounded by a negatively charged electron cloud. When placed in an external electric field, the external electric force pulls the electrons and nucleus apart, opposite to the intrinsic attraction between the nucleus and the electrons. The opposing forces balance each other with a slight shift between the center of masses of the nucleus and the electron cloud, resulting in a polarized atom. On the other hand, a few molecules, like water,...