肺结节的分类在2-[18F]FDG PET/CT图像中使用3D卷积神经网络
Victor Manuel Alves1,2, Jaime Dos Santos Cardoso3,4, João Gama1,4
1Faculty of Economics, University of Porto, Rua Dr. Roberto Frias, Porto, 4200-464 Porto, Portugal.
Nuclear medicine and molecular imaging
|January 23, 2024
概括
使用3D卷积神经网络 (CNN) 的深度学习模型在2-[18F]FDG PET图像上有效地区分恶性和良性肺结节. 这种人工智能方法有望提高肺结节管理中的诊断准确性.
科学领域:
- 医疗成像医学成像
- 人工智能的人工智能
- 在瘤学瘤学.
背景情况:
- 2-[F]FDG PET/CT对于肺结节的管理至关重要.
- 卷积神经网络 (CNN) 可能通过自动学习图像特征来增强恶性和良性肺结节之间的差异化.
研究的目的:
- 开发和验证CNN模型,使用2-[18F]FDG PET图像对肺结节进行分类.
主要方法:
- 对113名参与者的2-[18F]FDG PET图像进行了追溯分析.
- 培训和评估三种3D CNN架构 (堆叠3D CNN,VGG-like,Inception-v2-like) 和使用ResNet-50进行转移学习.
- 四重交叉验证和测试在一个持有的设置.
主要成果:
- 最终的堆叠3D CNN模型实现了ROC曲线下的面积为0.8385.
- 该模型在测试组上显示了80.00%的灵敏度,69.23%的特异性和73.91%的准确性.
- 使用了优化的决策值,优先考虑减少虚假阴性.
结论:
- 一个3D CNN模型在2-[18F]FDG PET图像上有效区分良性和恶性肺结节.
- 这种人工智能驱动的方法有可能提高肺结节的临床管理中的诊断准确性.
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