在治疗期间和治疗结束后,患有肺结核的青少年肺功能受损
Marieke M van der Zalm1, Vita W Jongen1,2, Ruan Swanepoel3
1Desmond Tutu TB Centre, Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
青少年结核病幸存者经常有持久的肺损伤,76%的患者在治疗期间表现出肺功能受损,65%的患者在治疗后表现出肺功能受损. 这凸显了对这一年龄段的肺结核后肺部疾病进行有针对性的研究的需要.
科学领域:
- 肺部医学 肺部医学
- 儿童传染病 儿童传染病
- 呼吸系统健康 呼吸系统健康
背景情况:
- 青少年的肺结核后肺病 (PTLD) 仍未得到充分研究.
- 肺结核 (TB) 可以导致长期的呼吸道并发症.
研究的目的:
- 在结核病治疗期间和之后评估青少年的肺功能.
- 为了比较结核病青少年与健康对照群之间的肺功能.
主要方法:
- 在南非对100名青少年 (50名结核病患者,50名对照) 进行前性研究.
- 肺功能通过螺旋计,囊造影,扩散能力和6分钟步行测试 (6MWT) 进行评估.
- 通过标准化螺旋计,囊造影和一氧化碳 (DLCO) 扩散能力标准定义的异常肺功能.
主要成果:
- 76%的结核病青少年在治疗期间有异常的肺功能,治疗结束后下降到65%.
- 与对照组相比,结核病的青少年表现出较低的螺旋计指数和增加的空气陷.
- 在治疗期间和治疗后,结核病青少年观察到步行距离的减少.
结论:
- 患有结核病的青少年经历了严重的肺功能障碍,这种障碍在治疗后仍然存在.
- 进一步的研究和临床试验对于管理青少年结核病相关的呼吸道发病率至关重要.
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