一个新的宏化物-Del-1轴在老年时再生骨
Kridtapat Sirisereephap1,2,3, Hikaru Tamura2, Jong-Hyung Lim4
1Division of Periodontology, Graduate School of Medical and Dental Sciences, Niigata University, Niigata 951-8514, Japan.
iScience
|January 23, 2024
概括
宏类抗生素和EM-523在老年小鼠中恢复骨再生的DEL-1. 这种宏化物-DEL-1轴促进骨生长,可能治疗与年龄相关的骨损失和牙周炎.
科学领域:
- 生物医学科学 生物医学科学
- 衰老研究研究 衰老研究
- 骨生物学 骨生物学 骨生物学
背景情况:
- 衰老会损害组织再生,增加对骨质损失疾病的易感性,如牙周炎.
- 骨形态遗传蛋白DEL-1对于骨再生至关重要,但随着年龄的增长,它的表达会减少.
- 了解与年龄相关的骨质损失背后的机制对于开发有效疗法至关重要.
研究的目的:
- 研究宏类抗生素和EM-523在恢复DEL-1表达和促进老年小鼠骨再生方面的潜力.
- 阐明DEL-1通路在调解这些化合物的骨再生作用中的作用.
- 评估针对与年龄相关的骨质损失的宏化物-DEL-1轴的治疗潜力.
主要方法:
- 对老年小鼠 (18个月大) 给予宏类抗生素和EM-523.
- 在牙周组织中评估DEL-1表达水平和骨再生.
- 评估骨质生成活性 (性酸酶,基因表达) 和骨质细胞生成.
- 与缺少DEL-1的小鼠进行比较,以确认路径依赖性.
主要成果:
- 在老年小鼠中,全身用宏类和EM-523恢复了DEL-1表达.
- 这些化合物显著促进了因年龄相关牙周炎而失去的骨再生.
- 骨再生依赖于DEL-1;在缺乏DEL-1的小鼠中没有观察到任何影响.
- 接受治疗的小鼠表现出增强的骨质生成活性,抑制骨质细胞形成,以及增加骨骨质量.
结论:
- 发现了一种新型的宏化物-DEL-1轴,能够在与衰老相关的疾病背景下再生骨.
- 宏类抗生素和EM-523代表了与年龄相关的骨损失和牙周炎的潜在治疗策略.
- 针对这一轴可能为老龄化人口的骨健康带来系统性益处.
相关概念视频
01:29Bone Disorders
3.5K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
3.5K
01:40Bone Remodeling
38.3K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
38.3K
01:31Osteoclasts in Bone Remodeling
2.9K
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
2.9K