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Updated: Jul 5, 2025

Author Spotlight: Quantitative Detection of DNA Protein Crosslinks and Their Post-Translational Modifications
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Published on: April 21, 2023

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通过Spd1激活检查点:一个基于竞争的系统,依赖于串联无序的PCNA绑定动机

Johan G Olsen1, Andreas Prestel1, Noah Kassem1

  • 1Structural Biology and NMR Laboratory, The Linderstrøm-Lang Centre for Protein Science and REPIN, Department of Biology, Ole Maaloes Vej 5, University of Copenhagen, 2200 Copenhagen N, Denmark.

Nucleic acids research
|January 23, 2024
PubMed
概括

这项研究揭示了Spd1中的第二个PCNA结合动机,这对DNA复制检查点激活至关重要. 这一发现突显出一个平衡的竞争系统,涉及PCNA,Spd1和Suc22R2进行细胞循环调节.

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