摩根氏菌感染的流行病学和临床特征:一个多中心的回顾性研究
Ahlam Alsaadi1, Abdulrahman A Alghamdi1, Layan Akkielah2
1King Abdullah International Medical Research Center, Riyadh, Saudi Arabia; King Saud Bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia.
Journal of infection and public health
|January 23, 2024
概括
摩根氏菌 (Morganella morganii) 的血流感染是严重的,通常耐抗生素. 患有并发症的老年患者面临着这种病原体的死亡风险更高.
科学领域:
- 医学微生物学 医学微生物学
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 摩根氏菌 (Morganella morganii) 是一种机会主义的格拉姆阴性病原体,会引起感染,特别是在免疫受损的个体中.
- 在M. morganii的抗生素耐药性使治疗复杂化,需要进一步研究其流行病学和毒性.
- 越来越多的人认为M. morganii是一种公共卫生威胁,这凸显了沙特阿拉伯需要有效的战略.
研究的目的:
- 调查沙特阿拉伯的M. morganii血流感染的特征,治疗和结果.
- 为了确定与M. morganii bacteremia.死亡相关的风险因素.
主要方法:
- 一项回顾性研究分析了2015年至2022年在沙特阿拉伯五家三级医院的M. morganii血流感染情况.
- 收集的数据包括患者人口统计,并发病,症状,抗生素耐药性模式,治疗方法和死亡率.
主要成果:
- 这项研究包括75名患者 (53-72岁) 患有高ICU入院率 (54%) 和高血压和糖尿病等常见并发症.
- 摩根菌对多种抗生素表现出耐药性;除了源控制措施外,碳烯是最常见的治疗方法.
- 观察到41%的住院死亡率,ICU患者,65岁以上患者和患有Klebsiella pneumoniae同时感染的患者的风险增加.
结论:
- 由于经常出现抗生素耐药性和高死亡率,M. morganii细菌症是一个重大的健康问题.
- 老年患者和那些患有潜在健康状况的患者特别容易受到致命的结果的影响.
- 有效的管理取决于源控制和明智的抗生素选择,以改善患者的生存率.
相关概念视频
Endocarditis II: Clinical Features of Infective Endocarditis
Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
Urinary Tract Infection III: Diagnostic Studies and Interprofessional Care
A healthcare provider can diagnose a urinary tract infection (UTI) through several methods:Medical History and Symptoms: The provider will take a detailed medical history and ask about symptoms such as frequent urination, burning sensation during urination, and lower abdominal pain.Urinalysis: A clean-catch urine sample is collected in a sterile container and tested for the presence of bacteria, white blood cells (leukocytes), nitrites, blood, and protein. The presence of leukocytes and...
Acute Pyelonephritis II: Diagnostic Studies and Management
Introduction:For diagnosing acute pyelonephritis, a comprehensive patient history is collected to identify symptoms such as dysuria, frequent or urgent urination, flank pain, or costovertebral angle (CVA) tenderness that may suggest a kidney infection.Physical ExaminationDuring the physical examination, CVA tenderness is assessed. This involves gentle percussion over the costovertebral angle, where tenderness often indicates a kidney infection.Diagnostic TestsUrinalysis: Used to identify white...
Atypical Pneumonia
Atypical pneumonia, often caused by Mycoplasma pneumoniae, is a form of pulmonary infection that differs from the classical presentation of bacterial pneumonia in both its cause and clinical symptoms. Mycoplasma pneumoniae is a pleomorphic bacterium notable for its lack of a rigid cell wall. This structural characteristic imparts resistance to beta-lactam antibiotics and significantly influences the bacterium’s behavior within the human host.Other pathogens responsible for the disease include...
Clinical Significance of Antibiotic Resistance
Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within the One...
Bacterial Meningitis II: Pathophysiology
Bacterial meningitis typically begins when pathogens such as Neisseria meningitidis and Streptococcus pneumoniae colonize the nasopharynx and invade the bloodstream. This process is facilitated by bacterial virulence factors, such as polysaccharide capsules, which resist phagocytosis and complement-mediated killing. Less commonly, bacteria reach the central nervous system via contiguous spread from infections like otitis media or sinusitis, through congenital or acquired dural defects, or...


