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Measuring the Stiffness of Ex Vivo Mouse Aortas Using Atomic Force Microscopy
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基于扩散的硬度预测的可重复性 - 一项健康志愿者研究

A-M Rasmussen1, A I Friismose1, B Mussmann2

  • 1Department of Radiology, Odense University Hospital, Odense, Denmark; Research and Innovation Unit of Radiology, University of Southern Denmark, Odense, Denmark.

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|January 23, 2024
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概括

扩散加权成像硬度 (DWI) 在健康的大脑中是可重复的,使用b200-1000 s/mm2的精度更好. 这种技术可以检测超过4.93%的硬度变化.

关键词:
大脑硬性 大脑硬扩散权重成像技术的使用.观察者之间的协议.在观察者内部的协议.可重复性 可重复性虚拟磁共振弹性图形 (Elastography) 是一种虚拟的磁共振弹性图形.

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科学领域:

  • 神经成像是一种神经成像.
  • 生物物理学的生物物理.
  • 医学物理 医学物理

背景情况:

  • 脑硬度是一个重要的生物机械性质.
  • 扩散加权成像硬度 (DWI硬度) 提供了一种非侵入性方法来评估大脑组织特性.
  • 了解DWIstiff的重复性对于其临床应用至关重要.

研究的目的:

  • 在健康志愿者中评估基于大脑扩散的硬度预测 (DWI硬度) 的可重复性.
  • 用两个不同的b值集 (b200-1500s/mm2和b200-1000s/mm2) 来比较DWI的重复性.

主要方法:

  • 31名健康志愿者接受了DWI影像检查,两组b值,每组扫描两次.
  • 两个观察员划出了感兴趣的地区.
  • 计算了可重复性系数 (RC),变化系数 (CV) 和布兰德-阿尔特曼一致度极限 (LoA).

主要成果:

  • 28名参与者完成了这项研究.
  • 重复性因大脑区域而异,大脑干显示最高的RCs (1.17对于DWI硬,1500和1.58对于DWI硬,1000).
  • 整个大脑CV为3.83%的DWI硬,1500和4.93%的DWI硬,1000. 观察者之间的和观察者内部的协议显示了可接受的LoA.

结论:

  • DWIstiff是评估大脑硬性的精确技术,尽管存在一些观察者依赖.
  • 与b200-1500 s/mm2相比,b200-1000 s/mm2 b值集的重复性更高.与b200-1500 s/mm2相比,b200-1000 s/mm2 b值集的重复性更高.
  • 在健康个体中,DWIstiff可靠地检测到超过4.93%的度变化.