对内分泌干扰化学品的混合暴露与美国老年人的认知功能之间的关联
1Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China; Ministry of Education Key Laboratory of Environment and Health, and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, People's Republic of China.
对内分泌干扰化学物质 (EDC) 的混合暴露可能会对老年人的认知功能产生负面影响. 这项研究分析了美国老年人的EDC代谢物水平和认知测试成绩,揭示了有关关联.
科学领域:
- 环境健康 环境健康
- 神经科学是一个神经科学.
- 老年学是一门学科.
背景情况:
- 有限的研究存在于混合内分泌破坏性化学物质 (EDC) 暴露的认知影响,特别是在老年人群中.
- 内分泌干扰化学物质是干扰荷尔蒙系统的环境剂,可能对神经健康构成风险.
研究的目的:
- 调查五类EDC混合暴露与美国老年人的认知功能之间的关联.
- 评估EDC代谢物对老年人认知表现的个别和综合影响.
主要方法:
- 这是一项横截面研究,利用了国家健康和营养检查调查 (2011-2014) 727名参与者的数据.
- 用即时回忆测试 (IRT),延迟回忆测试 (DRT),动物流利性测试 (AFT) 和数字符号替代测试 (DSST) 来测量47个EDC代谢物和评估认知功能.
- 应用三种分析方法,包括加权量子总和回归 (WQS) 和贝叶斯核机器回归 (BKMR),以评估EDC认知关系.
主要成果:
- 特定的EDCs,包括 perfluorononanoic acid,多二 (PCB) 199和PCB 206,与认知测试成绩有关.
- WQS回归表明混合EDC暴露与动物流利性测试 (AFT) 和全球z分数之间的负相关性,以及与延迟回忆测试 (DRT) z分数的积极相关性.
- BKMR分析显示EDC混合物和DRTz-score之间的积极趋势,但暴露低于中位数与DRT性能下降有关.
结论:
- 对内分泌干扰化学物质的混合暴露可能会对老年人的全球认知功能产生不利影响.
- 研究结果强调,需要采取措施限制EDC暴露,以保护老年人的认知健康.
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