在患有复发性复发性多发性硬化症的患者中查缺食症
Jan Kocica1, Nadezda Lasotova2, Jan Kolcava1
1Faculty of Medicine, Masaryk University, Brno, Czech Republic; Department of Neurology, The University Hospital Brno, Czech Republic.
Multiple sclerosis and related disorders
|January 23, 2024
概括
在多发性硬化症 (MS) 中,早期查消化不良 (吞困难) 是至关重要的. 结合多发性硬化症 (DYMUS) 问卷中的消化症和定时吞水测试 (TWST) 的结合,有效地识别出更多的患有多发性硬化症的风险患者,而不是单纯的问题.
科学领域:
- 神经学 神经学
- 临床医学 临床医学
- 康复 康复 康复 康复
背景情况:
- 缺食症是多发性硬化症 (MS) 中常见的,往往被诊断不足的症状.
- 它显著影响生活质量,并可能导致严重的并发症,如营养不良和吸入性肺炎.
- 早期检测食障碍对于及时干预和降低风险至关重要.
研究的目的:
- 为了比较一个简单的吞问题的诊断性能,多发性硬化症 (DYMUS) 问卷中的消化症和定时水吞测试 (TWST).
- 评估这些查方法在检测复发性复发性多发性硬化症 (RRMS) 患者的食障碍方面的有效性.
主要方法:
- 患有RRMS的患者使用简单的吞问题,DYMUS问卷和TWST进行了选.
- 呈阳性查结果的个体通过纤维光学内镜吞评估 (FEES) 提供了客观评估.
- 统计分析将查结果与人口统计和MS相关参数相关联.
主要成果:
- 15.1%的人报告主观吞困难;DYMUS在19.4%中呈阳性,TWST在16.8%中呈阳性.
- DYMUS和TWST的组合比简单的问题发现了更多患有食障碍的患者.
- 在94.6%的积极查患者中,FEES证实了食障碍,这表明其特异性很高.
结论:
- DYMUS问卷和TWST对于检测MS患者的消化不良比简单的问题更为敏感.
- 结合DYMUS和TWST可以提高识别风险人群的敏感性.
- 年龄,女性性别和更高的扩展残疾状态量表 (EDSS) 分数是MS中缺食症的潜在危险因素.
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