在体外通过体外血液净化程序去除蛋白质结合的保留溶液
Claudia Schildboeck1, Stephan Harm1, Jens Hartmann1
1Department for Biomedical Research, University for Continuing Education Krems, Krems, Austria.
Blood purification
|January 23, 2024
概括
血 perfusion 吸附剂显示出从血液中去除某些有毒代谢物的承诺,但与高度与蛋白质结合的物质作斗争. 将血液输血与血液透析相结合可能会在体外治疗中增强毒素的去除.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 肝病学 肝病学是一种肝病学.
- 生物医学工程 生物医学工程
背景情况:
- 和肝功能衰竭导致有毒代谢物的积累,导致严重的并发症.
- 传统的体外血液净化方法在去除这些毒素方面效率低下.
- 与蛋白质结合的保留溶液在血液净化方面构成了重大挑战.
研究的目的:
- 评估商业血 perfusion 吸附剂在去除与蛋白质结合的溶液中的有效性.
- 为了比较血液输血与常规血液透析用于毒素去除.
- 评估吸附剂适用于尿素和肝功能衰竭毒素的适用性.
主要方法:
- 在体外测试中,使用注射的人体血和全血,具有特定的尿素和肝脏毒素.
- 对每个保留溶液的蛋白质结合的确定.
- 血液输血 (Jafron HA,Biosky MG,Cytosorb) 与血液透析进行6个小时的比较.
主要成果:
- 血液透析有效地去除了希普酸,同型半氨酸,硫酸和酸.
- 细胞吸附在去除胆红素和胆酸方面表现出色.
- 杰弗朗HA和Biosky MG是除的最佳选择;没有一个除去3 - 碳基-4 - 甲基-5 - -2- furanpropionic 酸.
结论:
- 血 perfusion 吸附剂显示出可能去除特定的毒素,特别是胆红素和胆酸.
- 血液透析和输血的联合治疗可以改善整体毒素清除.
- 高度与蛋白质结合的代谢物仍然很难用当前的吸附技术去除.
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