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PARP 捕获是由 PARP 抑制剂解离速率常数控制的

Angelica A Gopal1, Bianca Fernandez1, Justin Delano1

  • 1Institute for Innovation in Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114; Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114.

Cell chemical biology
|January 23, 2024
PubMed
概括

聚 ((ADP-ribose) 聚合酶 (PARP) 抑制剂通过动力机制将PARP1捕获到DNA上,而不是物理停滞. 这种捕获效能与抑制剂的脱离率相关,澄清了癌症药物功能.

关键词:
修复DNA损伤的修复在PARP中,PARP是PARP.这是一种PARP抑制剂.在PARP陷中捕获PARP.PARP1 的第一部分.解离率是分离的速度.蛋白质的招募蛋白质的招募.

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