治疗阿片类药物使用障碍的药物与严重注射相关感染患者的再入院减少有关:一项匹配的队列研究
Nicole M Robertson1, Anthony A Mangino2, Anna-Maria South3
1Department of Internal Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Journal of substance use and addiction treatment
|January 23, 2024
概括
对注射药物 (PWID) 患有严重注射相关感染 (SIRI) 的人的患者指导性出院 (PDD) 显示了更高的再录取率. 在出院后开始治疗阿片类药物使用障碍 (MOUD) 的药物可以减少这些再入院.
科学领域:
- 传染性疾病 传染性疾病
- 成 药物 药物 药物 药物
- 医疗保健服务研究 医疗服务研究
背景情况:
- 由于严重注射相关感染 (SIRI) 和患者指导出院 (PDD) 的住院病例在注射毒品 (PWID) 的人群中正在增加.
- 关于专门针对通过PDD出院的PWID的再接收结果的研究有限.
研究的目的:
- 根据他们的出院状态,评估PWID中30天再入院的预测因素.
- 用SIRI来比较PDD和PWID标准释放之间的再接收率.
主要方法:
- 对148名被诊断患有SIRI的PWID进行了回顾性,匹配的队列研究.
- 用费舍尔的精确测试和后勤回归分析来评估再接收率和预测因素.
- 出院时治疗阿片类药物使用障碍 (MOUD) 的药物包括布普伦诺芬或甲.
主要成果:
- 对于PDD,30天再入院率明显高 (25.7%),相比于标准出院 (9.5%) (p=0.016).
- 出院时的情绪与30天再入院的几率降低有关 (OR=0.32,p=0.012).
- 错过超过7天的抗生素治疗增加了PDD患者的30天再入院几率 (OR=4.65,p=0.030).
结论:
- PDD与SIRI的PWID标准出院率高于30天的再入院率有关.
- 实施降低PDD发病率和增加MOUD发病率的策略可能会改善患者的治疗结果.
- 优化抗生素坚持是减少PDD患者再入院的关键.
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