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与苦味功能相关的基因与雄性小鼠的口味偏好和乙醇偏好之间的行为关联有关
Anna P Koh1, Molly I Smith1, Robin Dando1
1Department of Food Science, Cornell University, Ithaca, NY 14853, United States.
Physiology & behavior
|January 23, 2024
概括
味觉功能影响酒精偏好. 喜欢酒精的雄性小鼠显示苦味受体表达减少,这表明较弱的苦味信号有助于雄性更高的酒精摄入量.
科学领域:
- 神经科学是一个神经科学.
- 遗传学 是一个遗传学.
- 行为科学 行为科学
背景情况:
- 酒精使用障碍 (AUD) 是高度遗传的,遗传因素得到了广泛的研究.
- 酒精偏好的个人差异存在于遗传和社会因素之外.
- 乙醇 (酒精) 具有苦味和甜味的品质,这表明味觉功能可能起作用.
研究的目的:
- 调查味觉功能影响乙醇偏好的假设.
- 探索乙醇偏好的性别差异及其与味觉感知的关系.
主要方法:
- 使用小鼠模型来评估苦味 (素) 和甜味 (糖) 溶液的口味偏好.
- 在天然偏好或避免乙醇溶液的小鼠中比较口味偏好.
- 在雄性小鼠中分析了苦味受体和相关信号分子的mRNA表达水平.
主要成果:
- 在与味觉感知相关的乙醇偏好的明显性别差异.
- 偏爱乙醇的雄性小鼠也更喜欢 (苦),而偏爱乙醇的雌性小鼠更喜欢糖 (甜).
- 具有更高乙醇偏好的雄性小鼠对苦味受体 (T2R26,T2R37) 和GNAT3的mRNA表达减少,表明苦味信号较弱.
结论:
- 乙醇消费与味道反应有关,性别之间观察到不同的模式.
- 减少苦味信号可能导致雄性小鼠更喜欢乙醇.
- 这些发现可能对了解人类群体中药物滥用有影响.
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