净化的饮食会通过肠道微生物的改变影响肠道上皮质的增殖和屏障功能
Hiroaki Shiratori1,2, Kisara M Hattori1, Kazuaki Nakata2
1Division of Biochemistry, Department of Pharmaceutical Sciences, Faculty of Pharmacy, and Graduate School of Pharmaceutical Sciences, Keio University, Minato-ku, Tokyo 105-8512, Japan.
International immunology
|January 23, 2024
概括
一种原始的饮食支持肠道上皮质屏障功能,通过促进细分细丝细菌 (SFB) 殖民. 纯化的饮食会破坏这种屏障,部分原因是减少了SFB,在动物研究中影响了肠道平衡.
科学领域:
- 胃肠病学 胃肠病学
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
背景情况:
- 饮食显著影响肠道微生物群和粘膜屏障功能.
- 净化饮食对肠道平衡的作用尚不清楚.
- 纯化饮食通常用于动物研究.
研究的目的:
- 为了比较原始与纯化的饮食对肠道上皮质完整性和肠道微生物群的影响.
- 阐明饮食影响肠道屏障的机制.
主要方法:
- 在小鼠中比较原始和AIN-93G净化的饮食.
- 评估上皮层形态 (,隐形) 和营业额.
- 测量抗微生物产品 (REG3γ) 和上皮化.
- 使用16S rRNA基因测序分析肠道微生物组成.
- 研究代谢变化,包括脂肪酸氧化和生成.
主要成果:
- 纯化的饮食导致小/密室较短,上皮质的循环速度较慢,特别是在大肠.
- 抗微生物产品 (REG3γ) 和上皮化在净化的饮食养小鼠中减少.
- 净化的饮食改变了肠道微生物群,减少了细分丝状细菌 (SFB) 的丰富性.
- SFB损失与先天性淋巴细胞 (ILC3s) 减少的IL-22产生相关,影响REG3γ和fucosylation.
结论:
- 原始饮食通过SFB殖民促进上皮屏障功能.
- 纯化的饮食会损害上皮质屏障的完整性,部分原因是减少了SFB.
- 这些发现强调了在实验研究中需要考虑纯化饮食的影响.
关键词:
表面上皮质屏障的功能表皮代谢的代谢.我们的肠道微生物群.细分的丝状细菌细分的细分细菌细分的细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分细分相关概念视频
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