与代谢功能障碍相关的脂肪性肝病患者的饮食和药物治疗
Angelo Armandi1, Elisabetta Bugianesi1
1Department of Medical Sciences, Division of Gastroenterology, University of Turin, Italy.
European journal of internal medicine
|January 23, 2024
概括
代谢功能障碍相关的性肝病 (MASLD) 管理侧重于生活方式的改变和治疗代谢问题. 新兴的药理疗法显示,通过解决肝脏损伤和改善整体健康,对晚期代谢功能障碍相关的胆固醇肝炎 (MASH) 有前途.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 代谢疾病 代谢疾病
- 药理学 药理学是指药理学的学科.
背景情况:
- 代谢功能障碍相关的性肝病 (MASLD) 是一种与代谢综合征相关的肝病的范围.
- MASLD管理强调改变生活方式以改善代谢健康和胰岛素抵抗.
- 代谢功能障碍相关的脂肪肝炎 (MASH),一种严重的MASLD形式,可以发展为晚期肝病和纤维化.
研究的目的:
- 审查目前对MASLD的生活方式干预措施.
- 在II期和III期试验中总结纤维化MASH的药理方法.
- 突出新疗法的潜力,以解决MASH,逆转纤维化,并提供全身益处.
主要方法:
- 对MASLD的生活方式干预现有证据的审查.
- 在临床试验中分析纤维化MASH的药理疗法.
- 对MASH治疗的治疗目标和替代终点的评估.
主要成果:
- 生活方式干预,包括地中海式饮食,是MASLD管理的基础.
- 药理学药物的重要管道针对MASH解决和纤维化逆转.
- 新兴的疗法证明了超越肝脏健康的好处,影响血糖控制,脂质和体重.
结论:
- 改变生活方式和代谢并发症管理对于MASLD至关重要.
- 药物治疗正在为"有风险"的MASH推进,旨在逆转纤维化和MASH解决.
- 未来的MASH疗法需要在肝脏特定改善的同时证明生存益处.
相关概念视频
Lipid-Lowering Drugs: Statins and Miscellaneous Agents
661
Hyperlipidemia, a medical condition often referred to as high cholesterol, is characterized by abnormally elevated levels of lipids in the bloodstream. When present in excess, these lipids, specifically cholesterol and triglycerides, can lead to serious health complications, often involving cardiovascular diseases. Illnesses like atherosclerosis, heart attacks, and pancreatitis have all been linked to untreated hyperlipidemia. This means controlling and regulating cholesterol and triglyceride...
661
Chronic Pancreatitis II: Collaborative Care
92
The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:
Assessment:
92
Liver Physiology
554
The liver, an essential organ in the human body, performs over 200 vital functions that can be broadly categorized into metabolic, hematological, endocrine regulation, and bile production.
Metabolic Regulation:
The liver is the central organ involved in regulating blood composition. It stabilizes blood glucose levels, maintaining them within the range of 70–110 mg/dL. When these levels drop, the liver breaks down glycogen reserves and releases glucose into the bloodstream. It can...
Metabolic Regulation:
The liver is the central organ involved in regulating blood composition. It stabilizes blood glucose levels, maintaining them within the range of 70–110 mg/dL. When these levels drop, the liver breaks down glycogen reserves and releases glucose into the bloodstream. It can...
554
Ultrasound II: Endoscopic Ultrasound and FibroScan
107
Endoscopic Ultrasound (EUS) and FibroScan are valuable diagnostic tools in gastroenterology and hepatology, each with specific applications and techniques.
Endoscopic Ultrasound (EUS):
Endoscopic Ultrasound (EUS):
107
Diseases of the Liver and Gallbladder
540
Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
540
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
334
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
334


