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激活KIR/HLA-I组合作为成人B-ALL风险因素

Hossein Halimi1, Sara Mirzazadeh1, Kurosh Kalantar1

  • 1Department of Immunology, Shiraz Medical School, Shiraz University of Medical Sciences, Shiraz, Iran.

Human immunology
|January 23, 2024
PubMed
概括

在伊朗人中调查杀手细胞免疫球蛋白样受体 (KIR) 和人类白细胞抗原I类 (HLA-I) 组合,发现某些激活KIR/HLA-I模式与增加B细胞急性淋巴细胞白血病 (B-ALL) 易感性有关. 相反,较少的抑制性KIR/HLA-I组合可能会使个体易患B-ALL,原因是NK细胞功能受损.

关键词:
B细胞急性淋巴细胞白血病.人类白细胞抗原.免疫遗传学 免疫遗传学在KIR/HLA-I组合中,KIR与HLA-I相结合.杀手免疫球蛋白类受体的杀手免疫球蛋白类受体.

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