冷大气等离子体对与伤口相关的病原体具有杀菌作用,并且与烧伤伤口愈合相容
Mary A Oliver1, Lou'ay K Hussein1, Esteban A Molina1
1Firefighters' Burn and Surgical Research Laboratory, MedStar Health Research Institute, Washington, DC, United States; Department of Plastic and Reconstructive Surgery, Georgetown University School of Medicine, Washington, DC, United States.
Burns : journal of the International Society for Burn Injuries
|January 23, 2024
概括
阿塞斯冷血 (ACP) 有效地降低了伤口中的细菌负载,而不妨碍愈合. 这种新型抗菌剂在治疗烧伤和预防感染和痕方面表现有前途.
科学领域:
- 生物医学工程 生物医学工程
- 伤口治愈研究研究 伤口治愈研究
- 血医学是一种血医学.
背景情况:
- 烧伤感染增加了发病率和缩性痕.
- 现有的抗微生物药物可以阻碍细胞迁移等必要的愈合过程.
- 冷大气等离子体 (CAP) 提供了潜在的抗菌溶液,而不会损害宿主细胞.
研究的目的:
- 评估Aceso冷等离子体 (ACP) 在伤口愈合方面的疗效和安全性.
- 评估ACP在体外和体内对各种细菌物种的抗菌活性.
- 确定ACP对伤口愈合轨迹和过度缩痕指标的影响.
主要方法:
- 使用了一种新型的手持式Aceso等离子发生器来产生ACP.
- 在体外测试了ACP对细菌负载的抗菌作用.
- 应用ACP深部部分厚度和全厚度的伤口体内在不同阶段.
- 监测伤口愈合和评估多变性痕参数 (色差,弹性,TEWL,厚度).
主要成果:
- 在多种物种中,ACP在体外表现出强大的细菌消除能力.
- 与对照组相比,在体内用ACP治疗伤口显示生物负担降低.
- 而ACP应用并没有对伤口愈合轨迹产生负面影响.
- 在ACP治疗组和对照组之间,没有观察到过度缩痕指标的显著差异.
结论:
- 在急性烧伤中,ACP是一种潜在的有效抗菌剂,有助于在最终的手术关闭之前减轻感染.
- 在治疗具有延迟重新上皮质化的伤口时,ACP可能是有益的,从而降低了感染和缩性痕风险.
- 手持冷血设备提供了一种高效有效的方法,可以在不影响愈合的情况下减少伤口和手术部位的细菌负担.
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