两种单片双组合抗高血压疗法在中国患者中的比较:一个随机对照试验
Qi-Fang Huang1, Di Zhang1, Yihong Luo2
1Department of Cardiovascular Medicine, Centre for Epidemiological Studies and Clinical Trials, State Key Laboratory of Medical Genomics, Shanghai Key Laboratory of Hypertension, Department of Hypertension, The Shanghai Institute of Hypertension, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Ruijin 2nd Road 197, Shanghai, 200025, China.
BMC medicine
|January 23, 2024
概括
阿姆洛迪平/贝纳泽普利和贝纳泽普利/甲双疗法在中国患者中显示出相似的降血压 (BP) 效果. 阿姆洛迪平/贝纳泽普利显示,白天的血压降低更大,干咳的发病率更低.
科学领域:
- 心脏病学 心脏病学
- 药理学 药理学是指药理学的学科.
- 临床试验 临床试验
背景情况:
- 目前的高血压指导方针建议将ACE抑制剂或ARB与CCB或 thiazide利尿剂结合用于不受控制的高血压.
- 这两种组合策略的相对有效性和安全性,特别是在中国人群中,需要进一步研究.
研究的目的:
- 在中国高血压患者中,比较阿姆洛迪平/贝纳泽普利与贝纳泽普利/甲双疗法的降血效果和安全性.
主要方法:
- 一个多中心,随机,主动控制的试验,涉及560名符合条件的中国患者,患有1或2期高血压.
- 患者被分配给amlodipine/benazepril (5/10毫克) 或benazepril/hydrochlorothiazide (10/12.5毫克) 在24周内.
- 主要结局:24小时门诊静脉血压的变化. 安全性分析包括不良事件.
主要成果:
- 两种双重疗法都显示了可比的24小时门诊静脉血压降低 (安洛迪平/贝纳泽普利: -13.8±1.2 mmHg与贝纳泽普利/化亚: -12.3±1.2 mmHg; p=0.36).
- 阿姆洛迪平/贝纳泽普利显示,白天静脉血压的降低更大 (p=0.13),干咳的发病率显著降低 (5.3%对10.1%,p=0.04).
结论:
- 阿姆洛迪平/贝纳泽普利和贝纳泽普利/甲在中国患者的门诊静脉血压降低方面是可比的.
- 阿姆洛迪平/贝纳泽普利提供了一个潜在的优势,在白天更大程度上降低血压,降低干咳的风险.
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