阿尔茨海默病连续体中的亚临床型活动:与疾病的关联,认知和检测方法
Amber Nous1,2,3,4, Laura Seynaeve1,2, Odile Feys5,6
1Department of Neurology, Universitair Ziekenhuis Brussel (UZ Brussel), Brussels, Belgium.
Alzheimer's research & therapy
|January 23, 2024
概括
亚临床型活动 (SEA) 在阿尔茨海默病 (AD) 患者中更常见,随着疾病的严重程度而增加. 这种活动与AD的认知缺陷和特定的大脑体积变化有关.
科学领域:
- 神经科学是一个神经科学.
- 神经学 神经学
- 医疗成像医学成像
背景情况:
- 发作是阿尔茨海默氏病 (AD) 中已知的并发症.
- 亚临床型活动 (SEA) 可能存在于AD患者中,但未被标准EEG检测到.
- 这种疾病可能会加速阿尔茨海默氏症患者的认知衰退.
研究的目的:
- 为了确定在AD连续体中的SEA和间接性性泄漏 (IED) 的患病率,与健康对照对比.
- 为了比较长期EEG (LTM-EEG),高密度EEG (hd-EEG) 和磁脑电图 (MEG) 在检测SEA中的有效性.
- 基于临床,神经心理和神经成像数据,对患有SEA的AD患者进行表征.
主要方法:
- 招募了49名患有AD连续性的参与者和24名健康对照者.
- 使用LTM-EEG,hd-EEG和/或MEG来检测参与者的IED.
- 根据2011年NIA-AA标准诊断出AD连续性;对照组在认知上正常,粉样蛋白阴性.
主要成果:
- 在阿尔茨海默病患者中,SEA的患病率高于对照组 (31%),比对照组 (8%),随着疾病阶段的增加 (痴呆50%,MCI27%,临床前25%).
- 在50分钟内,MEG检测到的尖峰比LTM-EEG或hd-EEG更有效.
- 患有SEA的AD患者表现出更差的视觉空间和注意力得分,以及左额头,时和脑内皮层体积增加.
结论:
- 在AD连续性中,SEA更为普遍,并且随着疾病的进展而增加.
- 阿尔茨海默病中的SEA与更大的视觉空间和注意力障碍有关.
- 额头部,部和内腔区域的大脑体积增加与阿兹海默症患者的SEA有关.
关键词:
阿尔茨海默氏症是阿尔茨海默氏症的一种疾病.高密度的电脑电图 (EEG) 是一种高密度的电脑电图.间接性性排泄物 间接性性排泄物长期的脑电图.磁性脑电图 (MEG) 是一种磁性脑电图.亚临床型活动.更多相关视频
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