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ACE2和TMPRSS2多态的遗传关联与COVID-19严重程度;来自埃及的单一中心研究

Marwa H Elnagdy^1,2, Alshimaa Magdy¹, Waleed Eldars^2,3

¹Department of Medical Biochemistry and Molecular Biology, Mansoura University Faculty of Medicine, Mansoura, Egypt.

Virology journal

|January 23, 2024

概括

遗传因素影响COVID-19的严重程度. ACE2 rs2285666多态没有显示任何关联,但TMPRSS2 rs12329760 T等位基因可能会防止严重的COVID-19.

科学领域:

遗传学遗传学是一个
传染性疾病传染性疾病
分子生物学分子生物学

背景情况:

COVID-19对全球健康和经济造成了重大负担.
遗传因素可能会影响COVID-19的易感性和严重程度.
ACE2受体和TMPRSS2蛋白酶是SARS-CoV-2进入的关键.

研究的目的:

为了调查ACE2 rs2285666和TMPRSS2 rs12329760多形态和COVID-19严重程度之间的关联.
为了确定ACE2和TMPRSS2的遗传变异是否会影响疾病的进展.

主要方法:

对317名患有轻度至重度COVID-19的埃及患者进行横截面研究.
使用TaqMan实时聚合酶链反应,对ACE2 rs2285666和TMPRSS2 rs12329760进行基因定型.
对基因型相关的人口,临床和实验室数据的分析.

主要成果:

在ACE2 rs2285666多态和COVID-19严重程度之间没有发现显著的关联.
TMPRSS2 rs12329760小T等位基因和CT/TT基因型显著与严重COVID-19的可能性降低有关.
男性性别,高血压,糖尿病和高CRP水平与COVID-19的严重程度有关.

结论:

ACE2 rs2285666多态性似乎没有影响COVID-19的严重程度.
TMPRSS2 rs12329760 T等位基因可能会对严重的COVID-19产生保护作用.
需要进一步的研究来探索种族影响和并发症对这些遗传关联的综合影响.

关键词:

这就是ACE2ACE2.在 COVID-19 疫情中,埃及埃及埃及埃及基因型定制是指基因型定制.多态化多态化.这就是TMPRSS2的原因.

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