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Updated: Jul 5, 2025

A Comparative Approach to Characterize the Landscape of Host-Pathogen Protein-Protein Interactions
13:56

A Comparative Approach to Characterize the Landscape of Host-Pathogen Protein-Protein Interactions

Published on: July 18, 2013

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人类乳头瘤病毒E7蛋白诱导同源重组缺陷和PARPi敏感性

Siqi He1, Ao Wang1, Jing Wang2

  • 1Key Laboratory of Birth Defects and Related Diseases of Women and Children (Ministry of Education), Department of Gynecology and Obstetrics, Meishan Women and Children's Hospital, West China Second University Hospital, Sichuan University, Chengdu, 610041, People's Republic of China.

Journal of cancer research and clinical oncology
|January 23, 2024
PubMed
概括

人类乳头瘤病毒 (HPV) E7蛋白通过损害DNA修复来驱动宫癌中的基因组不稳定性. 这种由HPV诱导的同源重组缺陷 (HRD) 是用PARP抑制剂进行合成致死性治疗的目标.

关键词:
检查站检查站检查站检查站检查站修复DNA的修复DNA的修复这是一个HPVHPVHPV.这是一种PARP抑制剂.宫癌:子宫癌是一种癌症.

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