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过氧症阻止了新生儿在肺介质细胞多样性的动态增加

Fabio Zanini^1,2,3, Xibing Che^4,5, Nina E Suresh^4,5

¹School of Clinical Medicine, University of New South Wales, Sydney, Australia. fabio.zanini@unsw.edu.au.

Scientific reports

|January 23, 2024

概括

介质细胞 (MC) 对于肺部发育和修复至关重要. 肺部发育期间的高氧 (高氧) 暴露会破坏MC转录的进展,影响细胞通信,并导致新生儿肺部疾病的潜在治疗方法.

科学领域:

肺部生物学肺部生物学
发育生物学是发展生物学.
新生儿医学新生儿医学

背景情况:

肺血管新生对于肺形成至关重要,这是肺发育的最后阶段.
血管生成的干扰会导致肺部异常,如支气管肺功能障碍.
介质细胞 (MC) 在肺血管生成和肺膜化中起着至关重要的作用.

研究的目的:

在肺膜化过程中和对肺损伤的反应中对介质细胞进行分析.
了解介质细胞亚型在肺部发育和疾病中的作用.

主要方法:

单细胞转录组学单细胞转录组学
在发育中的肺组织的现场成像.
对介质细胞亚型及其转录组形状的分析.

主要成果:

鉴定出在出生时存在的特定介质细胞亚型,在膜化过程中增加多样性.
过氧暴露阻断了MC的转录基因进展,其中心细胞和肌纤维细胞是最脆弱的.
观察到细胞间通信的改变,以及高氧化后Acta1表达细胞的出现.

结论:

介质细胞多样性和转录组形状对于正常的肺部发育至关重要.
超氧引起的MCs中断提供了对新生儿肺部疾病病原体的见解.
这些发现可能会导致针对婴儿肺部疾病的向治疗.

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