语言流利模式与从轻度认知障碍到痴呆症的amnestic转换相关
Simona Cintoli1, Laura Favilli2, Riccardo Morganti3
1Department of Medical Specialties - Neurology Unit, AOUP, 56126, Pisa, Italy. s.cintoli@gmail.com.
Scientific reports
|January 23, 2024
概括
语言流利任务可以预测阿尔茨海默病转化在轻度认知障碍患者. 在基线音声口语流 (PVF) 的表现较低,确定了那些可能患上痴呆症的人.
科学领域:
- 神经科学是一个神经科学.
- 老年学是一门学科.
- 认知心理学 认知心理学
背景情况:
- 轻度认知障碍 (aMCI) 显著增加发展为阿尔茨海默病 (AD) 的风险.
- 早期识别可能转化为痴呆症的MCI个体对于及时干预至关重要.
- 神经心理学测试,特别是口语流度测试,正在被研究为潜在的预测标记.
研究的目的:
- 评估语音语言流 (PVF) 和语义语言流 (SVF) 任务在预测从aMCI转化为痴呆症方面的实用性.
- 确定特定的语言流度指标,可以作为认知衰退的可靠生物标志物.
主要方法:
- 一组61名aMCI患者 (65-80岁) 接受了基线神经心理评估,包括PVF和SVF任务.
- 参与者被跟踪了18个月,以确定转化为痴呆症.
- 使用接收器运行特征 (ROC) 曲线分析来评估VF测量的预测值.
主要成果:
- 14人 (23%) 在18个月内转化为痴呆症.
- aMCI转换器组在迷你心理状态检查和雷听力口语学习任务中得分明显较低,VF集群较少,PVF开关数在基线时较低.
- 在PVF中的集群数量显示了识别转换器的最高预测精度 (AUC = 0.80).
结论:
- 语言流的定性测量,特别是语音语言流集群,是预测MCI认知衰退的神经心理标志物.
- 更高的教育水平与在VF任务上的更好的表现有关,这表明教育对认知储备和表现的影响.
- 这些发现支持在临床环境中使用VF任务来早期对aMCI患者的风险分层.
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