在Sysmex XN系列中细胞群数据参数的参考间隔及其从韩国早期成年到老年年龄的变化模式
Yong Jun Choi1, Ju-Heon Park1, Seon Cho2
1Department of Laboratory Medicine, Chonnam National University Hwasun Hospital, Hwasun, South Korea.
International journal of laboratory hematology
|January 24, 2024
概括
这项研究确定了韩国人细胞群数据参数的特定年龄和性别的参考间隔. 这些参考间隔对于准确解释这些潜在的疾病查生物标志物至关重要.
科学领域:
- 血液学 血液学 血液学
- 临床化学 临床化学
- 生物标志物发现发现
背景情况:
- 细胞种群数据 (CPD) 参数是疾病查的潜在生物标志物,包括感染和骨髓质疏松综合征.
- 建立特定种群的参考间隔 (RIs) 对于准确的生物标志物解释至关重要.
研究的目的:
- 为了确定韩国人口中细胞群数据 (CPD) 参数的年龄和性别特定参考区间 (RI).
- 为使用CPD参数作为临床生物标志物提供基础.
主要方法:
- 分析了124,856名年龄在20-99岁的韩国受试者的数据.
- 在17个中心利用了来自Sysmex XN-2000仪器的细胞群数据 (CPD) 参数.
- 根据临床和实验室标准协会C28-A3指南计算的参考间隔 (RIs),考虑年龄和性别分区.
主要成果:
- 为各种细胞群数据 (CPD) 参数建立了特定于年龄和性别的参考间隔 (RIs).
- 确定了需要年龄和/或性别分区的特定参数,以便准确解释.
- 观察到侧向散射光强度和分布宽度以及光灯分布宽度的基于性别的差异.
结论:
- 成功确定了细胞群数据 (CPD) 参数的综合年龄和性别特定参考间隔 (RI).
- 这些已确定的RI对于验证从Sysmex XN-2000中获得的CPD参数的临床意义至关重要.
- 这些发现支持使用CPD参数作为临床诊断中的可靠生物标志物.
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