瘤沉积物独立地与结肠癌复发有关
Lynn Hakki1, Asama Khan1, Eric Do2
1Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
概括
瘤沉积物,焦点癌细胞聚合物,独立预测结肠癌患者的复发. 它们的存在,以及淋巴结转移,显著减少了复发的时间,突出了它们在风险评估中的重要性.
科学领域:
- 结肠直肠癌研究研究
- 手术病理学手术病理学
- 在瘤学瘤学.
背景情况:
- 瘤沉积物是皮脂肪中独特的癌细胞聚合物.
- 它们的预后意义仍在争论中,特别是在淋巴结阳性患者中.
研究的目的:
- 调查与瘤沉积相关的临床病理因素.
- 确定瘤沉积对淋巴结阳性和阴性结肠癌患者复发的影响.
主要方法:
- 对770名患有I-III期结肠癌的患者进行了回顾性分析.
- 由胃肠道病理学家进行的病理学审查.
- 排除直肠癌,转移和并发性恶性瘤.
主要成果:
- 在9%的患者中发现了瘤沉积物.
- 与淋巴结转移,高级T类,差异化,微卫星稳定亚型和入侵有关.
- 瘤沉积物 (HR 2.48) 和淋巴结转移 (HR 3.04) 独立地预测了复发时间的减少.
结论:
- 瘤沉积表明疾病更为晚期和高风险特征.
- 它们是复发的独立预测因素,即使在淋巴结阳性患者中也是如此.
- 患有瘤沉积和淋巴结转移的患者有明显更高的复发风险.
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