SOWAHB 多态性影响中国汉族人口甲状腺癌风险
Man Zhang1,2,3, Jing Liang1,2,3, Junhui Han1,2,3
1Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, School of Life Sciences, Northwest University institution, Xi'an, Shaanxi, China.
在SOWAHB中单核酸多态 (SNP) 与甲状腺癌 (TC) 风险有关. 具体来说,rs2703129可能会在汉族人口中提供保护,防止TC的发展.
科学领域:
- 遗传学和基因组学 遗传学和基因组学
- 癌症研究 癌症研究
- 流行病学 流行病学
背景情况:
- 甲状腺癌 (TC) 在全球范围内是一个重大的健康问题.
- 了解影响TC易受性的遗传因素对于风险评估和预防至关重要.
- SOWAHB基因在TC发育中的作用需要进一步研究.
研究的目的:
- 研究SOWAHB基因多态化与患甲状腺癌的风险之间的关联.
- 为了确定可能影响中国汉族人口中TC敏感性的特定SOWAHB变异.
主要方法:
- 在510名TC患者和509名使用Agena MassARRAY的对照组中,对SOWAHB变异的基因定型.
- 统计分析包括虚假阳性报告概率 (FRPP) 和SNP-SNP相互作用的多因素维度减小 (MDR).
- 根据年龄和性别进行分层分析.
主要成果:
- rs2703129 CC基因型与TC的可能性降低有关 (p=0.002).
- 在rs1874564 AG基因型中,TC的风险增加 (p=0.000).
- 在特定的年龄和性别小组中观察到显著的关联,rs2703129在老年人和男性中显示出保护作用,而rs1874564在老年人和女性中增加了风险.
结论:
- SOWAHB单核酸多态 (SNP) 与甲状腺癌的发生有关.
- rs2703129的多态性可能起到保护甲状腺癌的作用.
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