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二次环静脉和食管胃结的延展性在症状后的基金复制患者
Michelle M Lu1, Peter J Kahrilas1, Ezra N Teitelbaum2
1Kenneth C. Griffin Esophageal Center of Northwestern Medicine, Department of Medicine, Division of Gastroenterology and Hepatology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
患有积后症状的患者往往有异常的食道周平静止,这可能随着时间的推移而恶化或与EGJ外流阻力有关. 这项研究使用FLIP泛度测量来评估这些食道运动问题.
科学领域:
- 胃肠病学 胃肠病学
- 食道生理学 食道生理学
- 外科手术的结果
背景情况:
- 食道动力障碍显著影响患者经历囊复合手术后的症状.
- 在这些患者中,二次围心静止和食管胃结 (EGJ) 打开的精确生物力学仍然不完全理解.
研究的目的:
- 通过功能性流明成像探针 (FLIP) 泛米测量来研究二次围心和EGJ开放生物力学.
- 为了评估这些参数在症状成年患者的基金复制后.
主要方法:
- 基金复制后的87名成年患者接受了FLIP泛度测量,以评估症状的食道.
- 分析了二次围静收缩反应 (CR) 模式和EGJ打开指标 (EGJ延伸度指数[EGJ-DI]和EGJ最大直径).
- 数据与高分辨率测量仪 (HRM),患者报告的结果以及成像上的基囊复合完整性相关联.
主要成果:
- 异常的CR模式 (受损/失调或不存在) 是常见的 (47%),与囊切割后的较长时间和更宽的食道体有关.
- 患有异常CRs的患者显示EGJ-DI显著降低,表明EGJ外流阻力.
- 完整的基底复制与较高的正常CR比较于解剖异常的正常CR的比率相关.
结论:
- 具有症状的基金复制后患者经常表现出异常的二次围心.
- 食道动力不良可能会因经过基囊复合和/或EGJ外流阻力后的时间而加剧.
- 在这种患者群体中,FLIP泛度测量为食道功能和EGJ生物力学提供了宝贵的见解.
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