发展中国家源不明发烧的传染性原因:一项国际ID-IRI研究
Hakan Erdem1, Jaffar A Al-Tawfiq2,3, Maha Abid4
1Department of Infectious Diseases & Clinical Microbiology, Gulhane School of Medicine, Turkish Health Sciences University, Ankara, Turkey.
Journal of intensive medicine
|January 24, 2024
概括
在低收入国家,源不明的传染性发烧 (FUO) 通常是由结核病和心脏感染引起的. 这些情况是研究中发现的最严重和最常见的原因.
科学领域:
- 传染性疾病 传染性疾病
- 全球健康 全球健康
- 流行病学 流行病学
背景情况:
- 发病源不明的发烧 (FUO) 在发展中国家是一个重大挑战,需要进一步调查其传染病因.
- 了解FUO的原因对于改善资源有限的环境中患者的治疗结果至关重要.
研究的目的:
- 在中低收入国家 (LMIC) 和低收入国家 (LIC) 调查FUO传染病原因的频谱和特征.
- 确定这些地区与FUO相关的常见传染病原体和综合征.
- 评估与LMIC和LIC中传染性FUO相关的严重程度和死亡率.
主要方法:
- 从2018年1月到2023年1月进行了一项多中心研究,涉及7个国家的15个中心.
- 数据是通过传染病-国际研究倡议平台收集的,重点是已确认感染性FUO的成年患者.
- 使用快速序列器官衰竭评估 (qSOFA) 评分,重症监护室 (ICU) 入院,血管压缩剂使用和侵入性机械通风 (IMV) 来评估严重程度.
主要成果:
- 分析了160名患有传染性FUO的患者,92.5%患有社区感染.
- 结核病 (16.9%),传染性内心炎 (15.6%) 和疟疾 (13.1%) 是最常见的传染性综合征.
- 显著比例的患者需要接受ICU治疗 (16.2%),使用血管压缩剂 (8.8%) 或IMV (6.3%),总死亡率为9.4%.
结论:
- 结核病和心脏感染被确定为LMIC和LIC中最严重和主要的FUO感染原因.
- 这些发现强调了FUO中特定感染在资源有限的医疗保健机构中的关键作用.
- 针对这些普遍感染的向诊断和治疗策略对于管理这些人群中的FUO至关重要.
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