开发和描述潜在的杀性纳米乳液对抗艾滋病菌
Jonatas L Duarte1, Leonardo Delello Di Filippo1, Anna Eliza Maciel de Faria Mota Oliveira2
1Department of Drugs and Medicines, School of Pharmaceutical Sciences, São Paulo State University (UNESP), Araraquara, São Paulo, Brazil.
Beilstein journal of nanotechnology
|January 24, 2024
概括
和的纳米乳液提供稳定,环保的昆虫控制. 这些植物性杀虫剂具有较低的毒性和高的有效性,可以对抗疾病载体,如埃及蚊子.
科学领域:
- 农业科学 农业科学
- 环境科学 环境科学
- 纳米技术 纳米技术
背景情况:
- 植物性杀虫剂,如单烯,由于对环境的影响较低和耐药性免疫力,是可取的.
- 单烯的挑战包括溶解性和稳定性差,限制了它们在昆虫控制中的实际应用.
- 纳米乳液是一个有希望的基于纳米技术的解决方案来克服这些局限性.
研究的目的:
- 开发和描述用于杀虫剂应用的烯和烯纳米乳液.
- 评估这些纳米乳液的毒性在体外和体内.
- 为了评估杀虫剂对主要登革热载体的杀虫效果,Aedes aegypti.
主要方法:
- 纳米乳液是使用低能耗方法制成的.
- 描述包括水力动力直径和泽塔电位测量.
- 使用人类角质细胞 (HaCAT) 细胞和Galleria mellonella幼虫来评估毒性;针对Aedes aegypti幼虫进行了疗效测试.
主要成果:
- 成功生产了稳定的纳米乳液,其水力动力直径为~98nm (烯) 和~118nm (烯).
- 纳米乳液表现出超过60天的稳定性,受控释放,以及对人类细胞和幼虫的低毒性.
- 在50毫克/升的剂量下,观察到对Aedes aegypti幼虫的显著致命性.
结论:
- 纳米乳液有效地克服了单烯的可溶性和稳定性问题.
- 烯和烯纳米乳液显示出作为安全有效的生物杀虫剂的潜力.
- 这种纳米技术方法为控制蚊子传播的疾病提供了一个可持续的战略.
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