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在化学抗原受体T细胞治疗后的Trypanosoma cruzi重新激活

Bayan Alahmdi¹, Avneet Kaur², Samantha E Jacobs³

¹Division of Infectious Diseases, Department of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.

Open forum infectious diseases

|January 24, 2024

概括

化学抗原受体 (CAR) T细胞治疗可以导致Trypanosoma cruzi的重新激活,一种寄生虫感染. 这一案例凸显了在接受CAR T细胞治疗的免疫功能低下患者中需要保持警和积极查的必要性.

科学领域:

免疫学免疫学免疫学
传染性疾病传染性疾病
在瘤学瘤学.

背景情况:

化学抗原受体 (CAR) T细胞疗法是血液恶性瘤的革命性治疗方法.
在CAR T细胞治疗后的免疫抑制可以使患者易患机会性感染.
克鲁兹杆菌 (Trypanosoma cruzi) 是夏加斯病的致病原体,是拉丁美洲的特有病.

研究的目的:

在接受CAR T细胞治疗的患者中报告Trypanosoma cruzi重新激活的病例.
强调在免疫受损患者中考虑寄生虫感染的重要性.

主要方法:

案例报告. 情况报告.
审查患者的病史和诊断工作报告.
对Trypanosoma cruzi. 的寄生虫学和血清学检测.

主要成果:

患者在CAR T细胞输液后出现了与查加斯病再激活一致的症状.
诊断测试证实了活跃的Trypanosoma cruzi感染.
开始治疗查加斯病.

结论:

试素突细胞的重新激活是CAR T细胞治疗的潜在并发症,原因是严重的免疫抑制.
在接受CAR T细胞治疗的患者中,积极查和对寄生虫感染的监测至关重要,特别是那些有暴露史的患者.
早期诊断和治疗对于管理寄生虫的重新激活和改善患者的治疗结果至关重要.

关键词:

试osoma cruzi 是一种类型的虫.仿制性抗原受体T细胞疗法扩散大的B细胞淋巴瘤.血造细胞移植是血造细胞的移植.

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