Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

334
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
334
Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

186
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
186
Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

244
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
244
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

450
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
450
Irritable Bowel Syndrome I: Introduction01:17

Irritable Bowel Syndrome I: Introduction

276
Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
276
Disorders of the Male Reproductive System01:20

Disorders of the Male Reproductive System

419
Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....
419

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

The association between ejaculatory dysfunction and lumbosacral disorders: a systematic review of an underrecognized clinical link.

Sexual medicine reviews·2026
Same author

Endocrine-metabolic crosstalk in erectile dysfunction: mechanistic insights and therapeutic implications.

International journal of impotence research·2026
Same author

Safety and efficacy of the traditional Chinese medicine chaihu guizhi ganjiang decoction combined with wendan decoction in the treatment of premature ejaculation: an open-label retrospective cohort study on Chinese men.

Sexual medicine·2026
Same author

Response to comment on: Pre-spermatorrhea state: a novel therapeutic paradigm for the management of non-organic delayed ejaculation and anejaculation.

International journal of impotence research·2026
Same author

Pre-spermatorrhea state: a novel therapeutic paradigm for the management of non-organic delayed ejaculation and anejaculation.

International journal of impotence research·2025
Same author

Is Lumbar Disk Herniation a Potential Risk Factor for Chronic Prostatitis/Chronic Pelvic Pain Syndrome? Insights From a Misdiagnosed Case.

American journal of men's health·2025

相关实验视频

Updated: Jul 5, 2025

A TNBS-Induced Rodent Model to Study the Pathogenic Role of Mechanical Stress in Crohn's Disease
05:08

A TNBS-Induced Rodent Model to Study the Pathogenic Role of Mechanical Stress in Crohn's Disease

Published on: March 1, 2022

3.9K

炎症性肠病和勃起功能障碍之间的关系:一个双样本的门德尔随机化研究.

Dawei Gao1, Cheng Chen1,2, Ziliang Wu3

  • 1Clinical School of Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China.

Sexual medicine
|January 24, 2024
PubMed
概括

门德尔的随机分析发现没有遗传证据将炎症性肠病 (IBD) 与勃起功能障碍 (ED) 联系起来. 虽然观察性研究显示IBD患者的ED率较高,但这种遗传分析表明没有直接的因果关系.

关键词:
克罗恩氏病 克罗恩氏病是什么?门德尔的随机化这是勃起功能障碍.炎症性肠病是一种炎症性肠病.性结肠炎是一种

更多相关视频

Visualization of Estrogen Receptors in Colons of Mice with TNBS-Induced Crohn's Disease using Immunofluorescence
08:02

Visualization of Estrogen Receptors in Colons of Mice with TNBS-Induced Crohn's Disease using Immunofluorescence

Published on: March 12, 2020

6.6K
Chronic Salmonella Infection Induced Intestinal Fibrosis
08:40

Chronic Salmonella Infection Induced Intestinal Fibrosis

Published on: September 22, 2019

7.1K

相关实验视频

Last Updated: Jul 5, 2025

A TNBS-Induced Rodent Model to Study the Pathogenic Role of Mechanical Stress in Crohn's Disease
05:08

A TNBS-Induced Rodent Model to Study the Pathogenic Role of Mechanical Stress in Crohn's Disease

Published on: March 1, 2022

3.9K
Visualization of Estrogen Receptors in Colons of Mice with TNBS-Induced Crohn's Disease using Immunofluorescence
08:02

Visualization of Estrogen Receptors in Colons of Mice with TNBS-Induced Crohn's Disease using Immunofluorescence

Published on: March 12, 2020

6.6K
Chronic Salmonella Infection Induced Intestinal Fibrosis
08:40

Chronic Salmonella Infection Induced Intestinal Fibrosis

Published on: September 22, 2019

7.1K

科学领域:

  • 胃肠病学 胃肠病学
  • 泌尿器科 泌尿器科 泌尿器科 泌尿器科
  • 遗传学 是一个遗传学.

背景情况:

  • 观察性研究表明,在炎症性肠病 (IBD) 患者中,勃起功能障碍 (ED) 的患病率很高.
  • 没有确定IBD和ED之间的确切因果关系.
  • 调查潜在的遗传基础对于理解这种关联至关重要.

研究的目的:

  • 评估IBD (性结肠炎和克罗恩病) 和ED之间的潜在因果关系.
  • 使用孟德尔随机化 (MR) 分析来进行强大的因果推断.
  • 为了减轻混因素和观察性研究中固有的反向因果关系.

主要方法:

  • 使用IBD亚型和ED的全基因组关联研究 (GWAS) 数据进行了2个样本的MR分析.
  • 主要分析采用逆方差加权 (IVW) 方法,对次要分析采用MR-Egger和加权中位数方法.
  • 敏感性分析包括科克兰的Q测试,MR-Egger拦截,离开一个,和MR-PRESSO来评估异质性,性和异常值.

主要成果:

  • 门德尔随机分析 (IVW,MR-Egger,加权中位数) 没有显示出性结肠炎或克罗恩病对勃起功能障碍的显著因果作用 (P > .05).
  • 灵敏度分析证实了初步发现,表明没有实质性的异质性或定向性.
  • 补充方法的结果与IVW方法一致.

结论:

  • 这项研究没有为IBD和ED之间直接的因果关系提供遗传证据.
  • 尽管缺乏遗传联系,但在IBD患者中ED的高患病率需要临床关注,可能与心理因素有关.
  • MR 分析为调查因果关系提供了强大的工具,但GWAS 数据的局限性需要仔细解释.