肺移植后的肺栓塞与慢性肺合移植功能障碍的发展的关联
Justin C Magin1, Chun Xu2, Sarah Peskoe2
1Duke University Medical Center, Durham, NC.
Transplantation direct
|January 24, 2024
概括
肺移植后的肺栓塞 (PE) 与更糟糕的生存率和慢性肺异位移植功能障碍 (CLAD) 的更高风险有关. 肺栓塞严重性指数 (PESI) 评分不能可靠地预测肺移植接受者的这些结果.
科学领域:
- 肺部病理学 肺部病理学
- 移植手术 移植手术
- 心血管医学 心血管医学
背景情况:
- 肺栓塞 (PE) 是肺移植后的一种罕见但严重的并发症.
- 在PE时间/严重程度和慢性异位移植肺功能障碍 (CLAD) 之间的关系是不确定的.
研究的目的:
- 调查肺栓塞 (PE) 与肺移植接受者 (LTRs) 的结果之间的关联.
- 评估PE时间和严重程度对移植缺陷和CLAD发展的影响.
主要方法:
- 肺移植接受者 (LTRs) 的回顾性队列分析.
- 通过CT血管学或V/Q扫描确认PE诊断.
- 使用肺栓塞严重性指数 (PESI) 评分评估PE严重程度.
- 对整体存活率,移植失败和CLAD的分析.
主要成果:
- PE发生在6.14%的LTR中,随访时间中位数为1623天.
- 长期发育与增加的死亡率 (HR 1.8) 和移植失败 (HR 1.8) 有显著的关联.
- 乳腺发育也增加了患有CLAD的风险 (HR 1.7);仅仅心脏病发作并没有影响结果.
- PESI得分类别不是死亡或CLAD的重要预测因素.
结论:
- 肺移植受体 (LTRs) 的肺栓塞 (PE) 与生存率降低和慢性肺全移植功能障碍 (CLAD) 的风险增加有关.
- 肺栓塞严重性指数 (PESI) 评分不是这种患者群体中死亡率或CLAD的可靠预测指标.
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