益生菌Lactiplantibacillus plantarum在颗粒物相关的肺炎中的可能调节功能
Nishant Gupta1, N S Abd El-Gawaad2, Suhad Ali Osman Abdallah3
1Medical Research and Development, River Engineering, Greater Noida, India.
Frontiers in cellular and infection microbiology
|January 24, 2024
概括
接触细颗粒物 (PM2.5) 会导致呼吸系统问题. 补充益生菌Lactiplantibacillus plantarum显示出减少PM2.5引起的肺炎和过敏的潜力.
科学领域:
- 环境健康 环境健康
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
背景情况:
- 肺部疾病对全球健康构成重大挑战.
- 空气污染,特别是细颗粒物 (PM2.5),是呼吸系统健康的一个主要问题,可能导致过敏和过敏反应.
- 目前对PM2.5引起的呼吸系统问题的治疗有局限性.
研究的目的:
- 审查PM2.5如何触发呼吸道炎症和高反应性.
- 探索Lactiplantibacillus plantarum补充剂在减轻PM2.5相关的肺风险方面的潜力.
- 讨论L. plantarum有益作用背后的机制.
主要方法:
- 对PM2.5对呼吸系统健康影响的临床前证据的审查.
- 对L. plantarum的抗氧化特性和对细胞损伤标记物的影响进行分析.
- 通过L. plantarum对肠肺轴调节的研究.
主要成果:
- 暴露于PM2.5会导致氧化应激,炎症,脂质过氧化和肺部DNA损伤.
- 植物表现出抗氧化能力,减少PM2.5诱导的细胞损伤.
- 临床前数据表明,L. plantarum调节肠肺轴,影响SCFA和神经递质信号传递.
结论:
- L. plantarum可能通过抗氧化剂和肠肺轴调节提供对PM2.5诱导的肺炎的保护作用.
- 短链脂肪酸 (SCFA) 信号传递对于肺部恒温和气囊细胞防御至关重要.
- 需要进一步的研究来确定L. plantarum在肺部过敏中的治疗作用.
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