施用Centratherum anthelminticum种子改善了二型糖尿病患者的风险因子标志物
Hina Akram Mudassir1, Rukhsana Rubeen2, Shamim Akhter Qureshi3
1Department of Biochemistry, Federal Urdu University of Arts, Science & Technology, Karachi, Pakistan.
Pakistan journal of pharmaceutical sciences
|January 24, 2024
概括
在2型糖尿病患者中, Centratherum anthelminticum种子 (CAPca) 与甲胺相结合显著改善了血糖和糖化血红蛋白. 此外,CAPca在糖尿病患者和健康人群中增强了各种血清风险标志物.
科学领域:
- 药理学 药理学是指药理学的学科.
- 代谢障碍 代谢障碍 代谢障碍
- 草药是一种草药.
背景情况:
- 2型糖尿病 (T2D) 的管理往往需要多方面的方法.
- 甲胺是一种常见的第一线治疗,但额外的干预措施可能是有益的.
- (Centratherum anthelminticum) 的种子具有潜在的治疗特性.
研究的目的:
- 评估Centratherum anthelminticum种子 (CAPca) 对接受甲胺治疗的2型糖尿病患者的血液和血清风险因素的影响.
- 评估CAPca和甲福林在治疗T2D并发症中的协同作用.
主要方法:
- 一个为期3个月的随机,非盲目的,受控试验,涉及三个组:糖尿病测试 (DT,n=20),糖尿病控制 (DC,n=20) 和健康控制 (HC,n=20).
- 参与者每天服用:DC (甲素500mg),DT (CAPca囊+甲素500mg) 和HC (CAPca500mg) 的剂量.
- 禁食血糖,体重和血清生物化学标记被监测每周和在试验的开始和结束.
主要成果:
- 在T2D患者中,CAPca的使用导致了血糖% (p<0.0001) 和Hb糖化% (p<0.05) 的显著降低.
- 血清风险标志物显著下降:直接胆红素和尿酸 (p<0.01),肌酸酶和氨酸转移酶 (p<0.0001),肌素 (p<0.05).
- 在健康志愿者中,CAPca还显示了血液和血清标志物的改善.
结论:
- (Centratherum anthelminticum) 种子 (CAPca) 在治疗2型糖尿病时,与甲胺具有协同效应.
- 服用CAPca会对关键的血糖控制标志物和各种血清风险因素产生积极影响.
- 这些发现表明,CAPca是T2D管理及其相关代谢挑战的潜在辅助疗法.
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