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Updated: Jul 5, 2025

CD Spectroscopy to Study DNA-Protein Interactions
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转录因子MYC:MAX中的内在无序区域通过内部分子相互作用调节DNA结合

Stefan Schütz1, Christian Bergsdorf1, Sandra Hänni-Holzinger1

  • 1Novartis Institutes for BioMedical Research, Novartis Campus, CH-4056 Basel, Switzerland.

Biochemistry
|January 24, 2024
PubMed
概括

本质上有障碍的蛋白MYC是由分子内相互作用调节的,其DNA结合域与本质上有障碍的区域结合. 这些相互作用减缓MYC:MAX与DNA的结合,为药物发现提供了新的途径.

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