菌特类的生物合成
Pan Luo1, Jia-Hua Huang1, Jian-Ming Lv1
1Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education of China, Jinan University, Guangzhou 510632, China. tghao@jnu.edu.cn.
Natural product reports
|January 24, 2024
概括
菌特类循环酶对于发现新的天然产品至关重要. 本综述详细介绍了截至2023年8月的真菌特类循环和定制酶,强调了基因组挖掘的新发现.
科学领域:
- 自然产品生物合成 自然产品生物合成
- 菌类学 菌类学是指菌类学.
- 基因组学就是基因组学.
背景情况:
- 类化合物是具有多样性结构和生物活性的重要自然产品,包括像帕克利塔克塞尔和阿尔特米西宁这样的药物.
- 菌是特类的重要来源,它们的生物合成涉及特类循环酶和定制酶.
- 基因组挖掘,由测序和生物信息学驱动,是发现新型真菌类的关键策略.
研究的目的:
- 综合审查到2023年8月之前发现的所有真菌特类循环.
- 要突出新发现的类循环酶,特别是UbiA型循环酶,以及相关的定制酶.
- 从2015年到2023年8月,专注于真菌类发现的进展.
主要方法:
- 科学出版物的文献综述,截至2023年8月.
- 对基因组数据进行分析,以识别类环酶和在真菌中定制酶基因.
- 生物信息学方法用于表征新型酶功能.
主要成果:
- 识别和分类众多真菌类循环,包括I类,II类和UbiA型循环.
- 涉及真菌类修饰的各种定制酶 (细胞染色体P450s,黄素依赖的单氧基酶,乙烯转移酶) 的表征.
- 自2015年以来,通过真菌基因组挖掘发现新型类及其生物合成酶的数量显著增加.
结论:
- 菌类循环和定制酶代表了自然产品发现的丰富资源.
- 新兴的UbiA型循环层正在扩大已知的真菌类骨的多样性.
- 基因组挖掘和生物信息学的持续应用将加速从真菌中发现新的生物活性类的发现.
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